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Budding Yeast Ubiquitin Ligases Rad5 and Rad18 Bind a Novel PCNA Surface, which…

Fan(L),Du(Y),Novecosky(A),Luo(Y),Xiao(W) Int J Biol Sci None

...Rad18 and Rad5 are two E3 ligases responsible for PCNA mono- and poly-ubiquitination, respectively, at its K164 residue....

The Oligomeric State of Rad6-Rad18 and Its Interactions with Translesion Synthe…

Woodward(TJ),Ripley(BM),Ling(JA),Washington(… Biomolecules 2026-08-12

...Rad18 complex, freeing Rad18 monomers and dimers. Because pol η participates in non-mutagenic translesion synthesis, whi...

Elevation-associated shifts in plasma metabolite abundance and lung gene expres…

Zhang(X),Niu(Y),Men(S),Chen(Q),Tang(X) BMC Genomics 2026-01-20

...RAD18, RAD51), heat shock proteins (HSPB6, HSP40), and adhesion molecules (ADAM22, cadherins) was consistent with enhanc...

Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutag…

Anand(JR),Brown(BW),Lou(J),Gu(Q),Yang(Y),Dro… NAR Cancer 2026-03-00

...Rad18-/- tumors when compared with Rad18+/+ . Therefore, Rad18 promotes error-free bypass of 4NQO-induced DNA lesions an...

Novel HBx-interacting host cellular factors regulate dynamic nuclear and cytopl…

Ariumi(Y) Virology 2026-08-00

...Rad18 DNA repair enzyme, and CPSF6 cleavage factor were identified. DDX1, DDX3, and MOV10 colocalized with HBx in cytopl...

RAD18 facilitates cancer progression and immunosuppression via the AKT/mTOR/c-M…

Zhu(J),Huang(Q),Liang(Q),Yi(W) NPJ Precis Oncol 2026-05-11

...RAD18 as a potential pan-cancer prognostic biomarker and immunotherapeutic target, with targeting RAD18 holding promise ...

The backside β-turn is a key structural element of Rad6-family E2 ubiquitin-con…

Shukla(PK),Leng(AM),Chen(HH),Ganguly(R),Newe… Biochem J 2026-06-03

...Rad18-dependent PCNA monoubiquitination, and Ubr1/Ubr2-dependent polyubiquitination and degradation of Sml1 and N-end ru...

Advancing inducible gene-inactivation systems to explore synthetic lethality.

Sánta(ÁT),Gráf(A),Vincze-Kontár(K),Kovács(K)… NAR Cancer 2026-03-00

...RAD18 genes. Combining IGIS with cell survival, DNA fibre, BrdU alkaline comet assays, and pRPA immunostaining, we show ...

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic l…

Ashton(NW),Ravindranathan(R),Korchak(EJ),Som… bioRxiv 2026-05-10

...RAD18. This PIP motif is required for RAD18-dependent DNA damage-induced PCNA ubiquitination and PCNA turnover. Mutation...

Neuronal Injury and Regeneration-Linked Gene Expression Dynamics in the Hypotha…

Ulutabanca(H),Albayrak(S),Yilmaz Şükranli(Z)… Int J Mol Sci 2026-06-07

...Rad18, Avp, Gata3, and OxtR exhibited significant and region-specific expression changes. These findings demonstrate tha...

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