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The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.

Haber(Daniel A) Cell 2004-01-14

...BRCA2 inactivation. The implications for BRCA2 function are discussed.

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

Hughes-Davies(Luke),Huntsman(David),Ruas(M... Cell 2004-01-14

...BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3,...

BRCA2 deficiency in mice leads to meiotic impairment and infertility.

Sharan(Shyam K),Pyle(April),Coppola(Vincen... Development 2004-03-03

...Brca2 in gametogenesis has been obscure because of embryonic lethality of the knockout mice. We generated Brca2-null mic...

Recovery from DNA damage-induced G2 arrest requires actin-binding protein fil...

Meng(Xiangbing),Yuan(Yuan),Maestas(Adrian)... J Biol Chem 2004-03-30

...BRCA2, and lack of filamin-A expression results in increased cellular sensitivity to several DNA damaging agents in mela...

A simple tool for identifying unaffected women at a moderately increased or p...

Fisher(T J),Kirk(J),Hopper(J L),Godding(R)... Breast 2004-01-06

...BRCA2. The authors developed a short questionnaire to categorize risk according to breast cancer history in close relati...

A distinct phenotype characterizes tumors from a putative genetic trait invol...

Cleton-Jansen(Anne-Marie),Timmerman(Michel... Lab Invest 2004-03-24

...BRCA2 families. We were able to collect and review the tumor tissue samples from 34 patients with both breast- and carti...

Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsib...

Lee(Hyunsook) Exp Mol Med 2004-08-26

...BRCA2, is a tumor suppressor and individuals who inherit one defected copy of BRCA2 allele experience early onset breast...

Tamoxifen as chemoprevention in BRCA1 and BRCA2 mutation carriers with breast...

Peshkin(Beth N),Isaacs(Claudine),Finch(Cli... J Clin Oncol 2004-01-05

To assess physician recommendations about the use of tamoxifen in premenopausal BRCA1 and BRCA2 mutation carriers.,We ma...

Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and br...

Valarmathi(Mani T),Sawhney(Meenakshi),Deo(... Hum Mutat 2004-03-08

...BRCA2 (putative mutations - four novel) as well as fourteen amino acid substitutions were identified. Twelve BRCA1 and B...

A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid c...

Cetani(Filomena),Pardi(Elena),Viacava(Paol... Clin Endocrinol (Oxf) 2004-03-05

...BRCA2) in the differential diagnosis between benign and malignant parathyroid tumours by evaluating loss of heterozygosi...

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